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[Asn10,Leu11,D-Trp12]-pTH-Related Protein (7-34) amide (human, rat)

Name
[Asn10,Leu11,D-Trp12]-pTH-Related Protein (7-34) amide (human, rat)
Molecular structural formula
Purity
≥95%
CAS Number
129622-68-0
Formula
C162H254N50O36
MW
3478.11
Target
PTHR
Sequence
Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2
Sequence Shortening
LLHNL-{D-Trp}-KSIQDLRRRFFLHHLIAEIHTA-NH2
Solubility in DMSO
≥ 50 mg/mL
References
[1]. Nutt RF, et al. Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11. Endocrinology. 1990 Jul;127(1):491-3. [2]. Portal-Núñez S, et al. Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. Bone Joint Res. 2018 Jan;7(1):58-68.
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(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist.